Authors: Babenko V.V., Epanchintseva O.A., Yarosh V.A., Heart Institute Ministry of Health of Ukraine
The article presents a modern view at the problem of postoperative pain syndrome. The importance of its management is due to the impact on the duration and course of the recovery period. The pathophysiological mechanisms of primary and secondary sensitization, as well as the possibilities of pharmacological management are considered. Multimodal analgesia a combination of different analgesic medications – is the most justifiable approach of adequate postoperative pain relief. The advantages and disadvantages of possible combinations of analgesic medications depending on the type of surgical intervention are highlighted. The place of adjuvant drugs, in particular gabapentin or pregabalin, is shown in order to achieve the opioid-saving effect and minimize the side effects of opioid analgesics.
Key words: postoperative pain, analgesics, opioid-saving effect, pregabalin.
Published in the journal “Pain, Anesthesia and Intensive Care” № 2(87) ‘2019