Authors: O.Yu. Usenko, M.V. Manoilo, I.V. Babii, State Institution «O.O. Shalimov National Institute of Surgery and Transplantology» of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Abstract
Objective: to study the problem of erosive and ulcerative lesions of the upper gastrointestinal tract, the functional mechanisms for the protection of gastric mucosal barrier and to compare the effectiveness of the drugs used for prevention.
Materials and methods
The study analyzed the experience of treatment of 58 patients who underwent surgical intervention. All patients were prevented from developing erosive and ulcerative lesions of the gastroduodenal zone using proton pomp inhibitors (intraoperatively and in the early postoperative period), their effectiveness was compared.
Results
According to the study, Ulsepan (pantoprazole) compared with omeprazole has a greater efficacy in regulating the pH of the stomach and preventing the occurrence of stress lesions of the mucous membrane of the upper gastrointestinal tract.
Conclusions
Ulsepan (pantoprazole) is an effective and safe mean for preventing erosive and ulcerative lesions in patients at risk during surgical interventions.
Keywords: erosive and ulcerative lesions; stress ulcers; Ulsepan; pantoprazole