Changes in the functional state of the vascular endothelium, the level of C-reactive protein and cognitive functions in patients with atrial fibrillation and acute cerebrovascular accident under the influence of treatment

Authors: O.V. Kuriata1, Yu.S. Kushnir1, T.O. Vikhrova2

1 SI «Dnipropetrovsk Medical Academy of MH of Ukraine», Dnipro, Ukraine
2 ME «I.I. Mechnikov Dnipropetrovsk Regional Clinical Hospital», Dnipro, Ukraine

Abstract

Atrial fibrillation remains a basic cause of acute stroke (AS) that is a leading reason for death and severe prolonged disability. The agents aimed to prevent brain tissue impairment and improve recovery after AS are being searched. The purpose of the study was to determine the citicoline effects on vascular endothelium functioning, level of C-reactive protein and cognitive status in patients with atrial fibrillation and acute stroke. The results of the study demonstrated that all patients with atrial fibrillation and acute stroke developed endothelial dysfunction and cognitive impairment, 74 % of patients had elevated level of C-reactive protein. Citicoline administration at a dose of 1000 mg a day significantly improves vascular endothelium functioning and decreases the level of C-reactive protein that is of great importance in acute stroke as it helps to restrict tissue impairment in AS and improve prognosis in this cohort of patients.

Keywords: atrial fibrillation; acute stroke; treatment

Article in PDF
ARTICLES FROM CATEGORY
Support of educational events. Participation of World Medicine in the First Congress of Optometrists of Ukraine.
Cetirizine is an effective and safe antihistamine (literature review, results of clinical researches)
Опубліковано в журналі «Сучасна педіатрія. Україна» №8 (120) ’2021
All-Ukrainian Scientific and Practical Conference “Aspects of Internal Medicine in Wartime 2024"

PROVE YOU ARE A MEDICAL PROFESSIONAL

Attention: This section is intended for healthcare professionals only. If you are not a medical professional, you can return to the main page by clicking the “No” option

Yes
No

CARD-NOTIFICATION OF AN ADVERSE DRUG REACTION AND/OR LACK OF EFFICACY OF THE MEDICINE

INFORMATION ABOUT THE PATIENT

SUSPECTED AR/LE

Suspected AR (describe each clinical manifestation of the AR with dates and times of onset and end and outcome)/Indication of the LE

INFORMATION ABOUT SUSPECTED MEDICINES

INFORMATION ABOUT RELATED MEDICINES

(with the exception of drugs used to correct the effects of AR/LE)
(concomitant diagnoses, laboratory and instrumental studies, allergy history, pregnancy with gestational age, method of conception, pregnancy outcome (if the pregnancy ended, the date of delivery, type of delivery, etc.)

Information about the messenger

INFORMATION ABOUT THE MEDICAL/PHARMACY SPECIALIST

(if not the notifier)

MESSAGE CARD for the patient

to provide the patient and/or his/her representative with information on adverse drug reactions and/or lack of efficacy of the drug

INFORMATION ABOUT THE PATIENT

Information about the suspected medicine

Information on the prescription of the suspected medicinal product

Information about the messenger

Information about the physician, healthcare facility and place of residence of the patient who had an adverse medicine reaction and/or lack of efficacy of the medicine

розробка сайту Estetic web design