Authors: T.G. Romanenko, O.V. Morozova, O.M. Sulimenko
The objective: to reduce the frequency and severity of iron deficiency anemia (IDA) in multiple pregnancies by optimizing its prevention, treatment and proving the effectiveness and safety of the therapy.
Materials and methods
90 pregnant women were under observation. The control group (CG) consisted of 30 pregnant women with one fetus, group I – 30 women with multiple pregnancies who did not use the recommended therapy, group II – 30 women with multiple pregnancies, conducted according to our proposed method.
The effectiveness of therapy was evaluated weekly by subjective evaluation of improvement and according to laboratory parameters of peripheral blood.
General clinical methods included clinical, general blood analysis and determination of serum iron, quantitative determination of the concentration of sulfhydryl groups and lipoproteins in erythrocyte elements of peripheral blood, studied the surface architecture of erythrocyte membranes.
Results
There was a significant reduction in the frequency and severity of IDA in pregnant women of group II in 1.6 times.Diagnosed with a significant increase in the number of discocytes (group I 67.34±0.81; group II 84.53±1.04; p<0.05), a decrease in the number of ellipses (group I 0.99±0.05; group II 0,60±0.05; p<0.05); flat disks (group I 0.87±0.07; group II 0.56±0.03; p<0.05); dome-shaped (I group 2,41±0,14; ІІ group 1,82±0,11; р<0,05) and spherical erythrocytes (І group 4,11±0,12; ІІ group 2,44±0, 13; p<0.05). Significant decrease in the number of transitional forms (group I 3.41±0.31%; group II 2.53±0.21; p<0.05); pre hemolytic (I group 2,41±0,14%; ІІ group 1,44±0,11%; р<0,05) and degenerative forms (І group 1,18±0,14%; ІІ group 0,52 ±0.03; p<0.05), as well as the ratio of the inner and outer diameters of erythrocytes (group I 66.71±0.91; group II 45.81±0.63; p<0.05). There was a significant increase in the ratio of sulfhydryl groups and lipoproteins in erythrocyte membranes.
Conclusions
The complex composition of the drug Fersinol and Fersinol-Z, taking into account the effective antianemic action, can be considered optimal for the prevention and treatment of iron deficiency in multiple pregnancies and recommended for use in practical health care.
Key words: multiple pregnancy, iron deficiency anemia, prevention, treatment, Fersinol ampoules, Fersinol-Z (Fersinol-Z) capsules.