Clinical experience of using Cocarnite in the complex treatment of patients with ischemic heart disease and chronic heart failure

Authors: O.O. Khaniukov¹, Ye.D. Yehudina¹, O.G. Grigorenko², I.M. Osypchuk³

¹ State Institution «Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine»
² Dnipro Railway Clinical Hospital of Branch «Health Center» of the Joint stock company «Ukrainian Railway»
³ Communal establishment «City Clinical Hospital №11» of Dniprovsk Regional Council

Summary

The aim of study was to assess the effectiveness and safety of Cocarnit in the complex treatment of patients with ischemic heart disease and chronic heart failure. 60 persons with ischemic heart disease (stable angina pectoris, II – III functional class) and chronic heart failure (II – III functional class, NYHA classification) were included in our investigation. We performed standard clinical investigation, questioning, 6 minute walk test, definition of laboratory indices, electrocardiography, echocardiography, daily monitoring of electrocardiogram.

Patients were divided into two groups. 30 persons of main group took complex treatment – antithrombotic therapy (aspirin – 100 mg per day), beta-blocker (bisoprolol – 5-10 mg per day, depending on initial heart rate and blood pressure, with previous dose titration), ACE inhibitor (ramipril – 5-10 mg per day, depending on initial blood pressure, with previous dose titration), statin (atorvastatin – 40 mg per day) and, if necessary, nitrates and diuretics were recommended. 30 patients of main group additionally took Cocarnit (1 ampoule per day intramuscularly). Observation period was 12 – 14 days. The use of Cocarnit in the complex therapy of ischemic heart disease and chronic heart failure was associated with improvement of patients’ quality of life, significant decrease of the number and duration of angina attacks, reduction of the demand for short-acting nitrates, improvement of the functional class of chronic heart failure, increase of walking distance during 6 minutes walking test. Besides, complex therapy with Cocarnit was well tolerated by patients – serious adverse effects of treatment were not registered.

Key words: ischemic heart disease, chronic heart failure, treatment, Cocarnit.