Authors: A.S. Svintsitskyi, N.P. Kozak, I.V. Korendovych, O.V. Barabanchyk, National Medical University named after O.O. Bogomoletsa, Kyiv
The article presents the results of a study of bile colloidal properties and biochemical parameters of liver functional state and lipid metabolism in patients with nonalcoholic fatty liver disease combined with hyperuricemia. In patients with hyperuricemia, the increased levels of cholic and deoxycholic acids and the decreased level of taurocholic acid were more frequently observed. Imbalance between these parameters and shift of bile pH to the acid side increase bile lithogenic properties, that contributes to the formation of gallstones. The use of ursodeoxycholic acid, rosuvastatin, and allopurinol in these patients improves clinical symptoms, normalizes biochemical parameters of liver functional state and lipid metabolism and also the spectrum of bile acids.
Keywords: nonalcoholic fatty liver disease, hyperuricemia, biliary sludge, bile acids, ursodeoxycholic acid.