Some aspects of the pathogenetic effect on the GABA system

Authors: M.A. Trishchynska (1), M.V. Polivoda (2)

(1) Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
(2) O.S. Luchanskyi Kherson City Clinical Hospital, Kherson, Ukraine


The article presents up-to-date data on the structure, classification, differences between different types of gamma-aminobutyric acid (GABA) receptors and their prevalence. Given this information, some links in the pathogenesis of neurological di-seases become clear. At the same time, the impact on GABAergic neurotransmission opens new possibilities for both symptomatic and pathogenetic treatment of neurological disorders. One of the unusual effects on the GABAergic system at different levels of the central nervous system is muscle relaxation.

Keywords: γ-aminobutyric acid; GABA receptors; inhibitory system of the central nervous system; neurotransmission; muscle relaxant

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